illegitimate recombination การใช้

• Strand slippage deletion ( illegitimate recombination ) may be responsible.
• In these mycobacteriophages, genetic assortment may be the result of repeated instances of site-specific recombination and illegitimate recombination ( the result of phage genome acquisition of bacterial host genetic sequences ).
• The Bloom syndrome protein interacts with other proteins, such as topoisomerase III? and RMI2, and suppresses illegitimate recombination events between sequences that are divergent from strict homology, thus maintaining genome stability.
• Specifically, this protein functions as a member of a multi-protein complex known as shelterin, that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation.
• Also, because eukaryotic constructs rely on illegitimate recombination, a process by which the transgene is integrated into the genome without similar genetic sequences, and not homologous recombination, which inserts at similar sequences, they cannot be targeted to specific locations within the genome, unless the transgene is co-delivered with genome editing reagents.